Application of Stable Isotope Labeled Compound for Mass Spectrometry Analysis.
نویسندگان
چکیده
منابع مشابه
Regression analysis for comparing protein samples with 16O/18O stable-isotope labeled mass spectrometry
MOTIVATION Using stable isotopes in global proteome scans, labeled molecules from one sample are pooled with unlabeled molecules from another sample and subsequently subjected to mass-spectral analysis. Stable-isotope methodologies make use of the fact that identical molecules of different stable-isotope compositions are differentiated in a mass spectrometer and are represented in a mass spectr...
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Lipids are ubiquitous molecules which serve a variety of important biological functions, including energy storage (triglycerides), modulation of cellular membrane structure and function (phospholipids and cholesterol), intracellular signaling and hormonal regulation. Dysfunctions of lipid metabolism contribute to a variety of diseases including, among others, atherosclerosis, hypertriglyceridem...
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Activity-based protein profiling has emerged as a valuable technology for labeling, enriching, and assessing protein activities from complex mixtures. This is primarily accomplished via a two-step identification and quantification process. Here we show a highly quantitative and streamlined method, termed catch-and-release activity profiling of enzymes (CAPE), which reduces this procedure to a s...
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ژورنال
عنوان ژورنال: Journal of the Mass Spectrometry Society of Japan
سال: 1998
ISSN: 1340-8097,1880-4225
DOI: 10.5702/massspec.46.191